Thrombocytosis Treatment and Medical Care

Treatment of thrombocytosis should be individualized based on risk factors, which include: cardiovascular risk factors(smoking, hypertension, etc.), thrombocytosis histroy, Platelet count greater than 1.5 million x 109/L.

Hydroxyurea, interferon alfa and anagrelide are drugs among treatment of choice for thrombocytopenia. Low dose aspirin has also shown some benefit during treatment. Moreover, plateletpheresis has shown to be beneficial for a prompt decrease in platelet count is case of emergencies and acute

Lifestyle modifications such as smoking cessation, weight loss and exercise are essetial to patients with primary thrombocytosis. Studies have shown the benefit of hydroxyurea treatment for patients with thrombocytosis in decreasing the platelet count; moreover, a clinical trial has shown the overall benefit of taking hydroxyurea and aspirin over anagrelide and aspiring combination, as far as thrombocytosis treatment and less experienced side effects and risk for the patient. Another clinicla control trial has shown that low-dose aspirin by itself may be beneficial in treatment of low-risk patients. 

http://bloodjournal.hematologylibrary.org/content/117/5/1472.full